Method and composition for modulating erythropoiesis

摘要

The invention generally relates to compositions and methods of their use. More specifically, the invention relates to the use of a compound in modulating erythropoiesis in a subject by mediating the activity and/or quantity of a member present in the LPA3-mediated signaling pathway, such as lysophosphatidic acid receptor subtype 3 (LPA3).

主权项

1. A method for modulating erythropoietin-dependent erythropoiesis via Lysophosphatidic acid receptor subtype 3 (LPA3) in a subject comprising administering to said subject a compound capable of mediating Lysophosphatidic acid receptor subtype 3 (LPA3) wherein the compound is selected from the group consisting of LPA, 2-arachidonoyl-LPA, sphingosine 1-phosphate (S1P), lysophosphatidyl choline (LPC), sphingosylphosphorylcholine, 1-oleoyl-2-O-methyl-rac-glycerophosphothionate (OMPT), (3S)-1-fluoro-3-hydroxy-4-butyl-1-phosphonate (XY-17), T13, T10, VPC12086, VPC31143, mono-fluorinated LPA, 3-[({4-[4-({[1-(2-chloro-4-methylphenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid (Ki16425), diacylglycerol pyrophosphate (DGPP), VPC12249, dioctyl-PA, 1-O-acyl-α-fluoromethylenephosphonate, α-hydroxymethylenephosphonate LPA, and pharmaceutically acceptable salts thereof.