发明名称 |
Agents for reversing epigenetic silencing of genes |
摘要 |
The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided. |
申请公布号 |
US9034574(B2) |
申请公布日期 |
2015.05.19 |
申请号 |
US200712521109 |
申请日期 |
2007.12.21 |
申请人 |
The Johns Hopkins University |
发明人 |
Nelson William G.;Yegnasubramanian Srinivasan;Lin Xiaohui;Speed Traci J.;Reichert Zachery |
分类号 |
A61K31/4184;G01N33/50;G01N33/68 |
主分类号 |
A61K31/4184 |
代理机构 |
DLA Piper LLP (US) |
代理人 |
DLA Piper LLP (US) |
主权项 |
1. A method of treating prostate cancer in a subject, comprising administering to the subject a methylbinding domain (MBD) pathway antagonist of structural Formula III: |
地址 |
Baltimore MD US |