Methods and compositions for sustained delivery of drugs

摘要

The present disclosure relates to methods and compositions for the topical sustained delivery of therapeutic agents. Topical application of compositions containing a muscle fasciculating agent result in the sustained release of any therapeutic agent contained within the composition. More particularly, topical application of such compositions to the outer surface of the eyelid of a patient results in increased absorption and sustained release of the therapeutic agent into the eyes or systemically.

主权项

1. A method for treating an ophthalmic condition of the surface or interior of the eyeball or an ocular gland in a human patient in need thereof comprising topically administering a composition to the outer surface of at least one upper eyelid of the patient, said composition comprising (1) a therapeutically effective amount of at least one therapeutic agent effective for treatment of the ophthalmic condition, (2) from 0.001% to 50 wt % of a muscle fasciculating agent selected from the group consisting of caffeine, theobromine, theophylline and pentoxifyline and (3) a pharmaceutically acceptable carrier, wherein said therapeutic agent is selected from the group consisting of anti-glaucoma agents, vasoconstrictors, vasodilators, anticholinergic agents, cholinergic agents, α-agonists, β-agonists, anti-inflammatories, secretogues, antibiotics, mast cell stabilizers and combinations thereof, wherein said administration results in delivery of the therapeutic agent across the eyelid and to target tissue of the eyeball or ocular gland.