Syndecan peptides and polypeptides as inhibitors of cancer

摘要

The invention provides for peptides from syndecan 4 and methods of use therefor. These peptides can inhibit α6β4 integrin interaction with EGFR, thereby preventing tumor cell growth and tissue invasion.

主权项

1. A method of inhibiting the interaction of α6β4 integrin on the surface of a cancer cell with EGFR in a subject comprising administering to said subject a peptide segment consisting of between 45 and 100 amino acid residues and comprising about 45 residues of SEQ ID NO:1 including residues 87-131 (SEQ ID NO: 4) such that said cancer cells are contacted by said peptide.