Multi-modality nanoparticles having optically responsive shape

摘要

In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.

主权项

1. A layered nanoparticle characterized by having a first concave external surface and a second convex external surface, said nanoparticle comprising:
a first biocompatible layer comprising a first surface and a second surface, the first surface being substantially concave and forming said first concave external surface of the layered nanoparticle; a second biocompatible layer comprising a first surface and a second surface, the second surface being substantially convex and forming said second convex external surface of the layered nanoparticle; wherein the first biocompatible layer ranges in thickness from about 1 nanometer to about 50 nanometers, wherein the inner core material ranges in thickness from about 1 nanometer to about 100 nanometers, and wherein the second biocompatible layer ranges in thickness from about 1 nanometer to about 50 nanometers and an inner core material encapsulated between, the first and second biocompatible layers.