Reference plant, a method for its production, extracts obtained therefrom and their use

摘要

The invention relates to a reference plant which has been selected to:
a) not express a medicinally active compound or group of compounds; yetb) express, at least substantially qualitatively, most other non medicinally active compounds present in a therapeutically active comparator plant.;The reference plant can be used to generate a reference extract with a reference chemical profile which resembles that of the comparator plant less the active compound or group of compounds and may thus be used as a placebo or to otherwise test the hypothesis that the active compound or compounds are responsible for an extracts perceived medicinal activity.

主权项

1. An inbred reference Cannabis sativa plant characterized in that it:
a) comprises stalked glandular trichomes having small dull heads free of white trichomes, b) does not express cannabinoids; yet expresses a profile of entourage compounds quantitatively substantially similar to a profile of entourage compounds of a comparator Cannabis sativa plant which expresses cannabinoids from which it has been bred, and c) comprises a cannabinoid knock out factor or monogenic mutation that blocks cannabinoid biosynthesis in Cannabis sativa governing a reaction in the pathway towards the phenolic moieties olivetolic and divarinic acid, wherein the source of said cannabinoid knock out factor or monogenic mutation is Cannabis sativa industrial hemp cultivar USO-31 deposited as NCIMB Accession number 42357.