Compositions and methods for silencing SMAD4

摘要

The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target SMAD4 gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating anemia of inflammation in humans).

主权项

1. A composition comprising an interfering RNA that silences SMAD4 gene expression, wherein the interfering RNA is an siRNA that comprises a sense strand and a complementary antisense strand, wherein the siRNA is Identifier 3 (SEQ ID NO:7 and SEQ ID NO:8).