STRUKTUR AF DEN C-TERMINALE REGION AF INSULIN-RECEPTOREN ALFA-KÆDE OG AF DEN INSULIN-LIGNENDE VÆKSTFAKTOR RECEPTOR ALFA-KÆDE

摘要

The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IRα-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.