N [5 (AMINOSULFONYL) 4 METHYL 1 3 THIAZOL 2 YL] N METHYL 2 [4 (2 PYRIDINYL)PHENYL]ACETAMIDE MESYLATE MONOHYDRATE HAVING A SPECIFIC PARTICLE SIZE DISTRIBUTION RANGE AND A SPECIFIC SURFACE AREA RANGE FOR USE IN PHARMACEUTICAL FORMULATIONS.

摘要

The present invention relates to the crystalline mesylate monohydrate salt of N [5 (aminosulfonyl) 4 methyl 1 3 thiazol 2 yl] N methyl 2 [4 (2 pyridinyl)phenyl]acet amide in a definite particle size distribution and a specific surface area range which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions as well as to pharmaceutical compositions containing said N [5 (aminosulfonyl) 4 methyl 1 3 thiazol 2 yl] N methyl 2 [4 (2 pyridinyl)phenyl]acetamide mesylate monohydrate having the afore mentioned particle size distribution and specific surface area range.