| 摘要 |
<p>Benzimidazoles of formula (I): wherein: A is 5-to 12-membered aryl or 5-to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, -(CH2) -, -X-, -CH2-X-, or -X-CH2- ; X is -0-, -S-, -N(R2)-, >C=0, >S(=0), >S(=0) 2, -0-C(=0)-, -C(=0)-0-, N(R )-C(=0)-, or -C(=0)-N(R 2)-; each L is independently a single bond, Ci. alkylene, C2. o alkenylene or C2. alkynylene; R'is Ci.6alkyl, C2.6alkenyl or C2.6alkynyl, each of which is unsubstituted or substituted; each Z is in de pendently -N(R )2, -OR2, -SR2, -S(=0)R 2, -S(=0) 2R2; each R2 is independently hydrogen, Ci- alkyl, C2 alkenyl or C2 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; o and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.</p> |
