RECOMBINANT MICROORGANISM FOR THE PRODUCTION OF USEFUL METABOLITES

摘要

Described are recombinant microorganisms characterized by having phosphoketolase activity having a diminished or inactivated Embden Meyerhof Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose 6 phosphate dehydrogenase or by reducing glucose 6 phosphate dehydrogenase activity as compared to a non modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone isobutene or propene.