发明名称 |
ETANERCEPT FORMULATIONS STABILIZED WITH COMBINATIONS OF SUGARS AND POLYOLS. |
摘要 |
The present invention is a stable aqueous pharmaceutical composition comprising etanercept in combination with stabilizers to reduce instability, aggregation misfolding and/or fragmentation of the etanercept during storage of the formulation; said stabilizer comprising a combination of a sugar and a polyol. Various technical terms used in the following discussion are defined below in the section entitled "Definitions" and throughout the remainder of the specification. The stabilized etanercept formulations of the present invention which ar optionally and preferably free of arginine, elicit long term storage stability. |
申请公布号 |
MX2014004734(A) |
申请公布日期 |
2015.05.15 |
申请号 |
MX20140004734 |
申请日期 |
2012.10.18 |
申请人 |
COHERUS BIOSCIENCES, INC. |
发明人 |
MANNING, MARK;MURPHY, BRIAN |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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