BENZOTHIAZINONE DERIVATIVES AS ANTI TUBERCULOSIS AGENTS

摘要

Mycobacterium tuberculosis2332141414141412314343414Novel benzothiazinone derivatives of formula (I) or pharmaceutically acceptable salts or solvates thereof have been found to be effective against strains and may thus be useful in the treatment of tuberculosis: wherein EWG (electron withdrawing group) = NO CN CF F Cl Br OCF OH OR OCHF COOR wherein R is hydrogen or a straight or branched C C alkyl group X = a bond or a straight or branched C C alkylene group which may be substituted with a group selected from F Cl Br I or C C alkoxy; Y = hydrogen a straight or branched C C alkyl group OH or OR wherein R is hydrogen or a straight or branched C C alkyl group; n = 0 1 or 2; R R = hydrogen or substituent (s) which may be the same or different from each other and are selected from the group consisting of D F Cl Br CF a straight or branched C C alkyl group a phenyl group OR SR NRR wherein R R R may be the same or different from each other and are hydrogen or a straight or branched C C alkyl group or a phenyl group.