发明名称 |
ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED ANTIBODY VARIABLE REGION |
摘要 |
The inventors have succeeded in creating an antigen-binding molecule containing an antibody variable region, the molecule having binding activity to a molecule expressed on the surface of T cells and to a molecule expressed on the surface of another immune cell, but not binding simultaneously to both. The present invention enables the creation of an antigen-binding molecule that can prevent side effects that can occur when T cells and other immune cells crosslink, and provides an antigen-binding molecule that is suitable as a drug. |
申请公布号 |
WO2015068847(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
WO2014JP79785 |
申请日期 |
2014.11.11 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;KADONO, SHOJIRO;HIRONIWA, NAOKA;SAKURAI, MIKA |
分类号 |
C12N15/09;A61K39/395;A61P35/00;C07K16/28;C07K16/30;C07K16/46 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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