发明名称 |
RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS (RSV) AND CACCINES |
摘要 |
Described herein is a recombinant respiratory syncytial virus (RSV) having an attenuated phenotype. In one embodiment, recombinant RSV includes an M2-2 protein with a mutation that renders the M2-2 protein inactive or prevents expression of the M2-2 protein. In one embodiment, the amino acid at position 66 in the F subunit has a positively charged side chain. Nucleic acids encoding recombinant RSV are also described, as well as vectors containing the nucleic acids. |
申请公布号 |
WO2015041924(A3) |
申请公布日期 |
2015.05.14 |
申请号 |
WO2014US55151 |
申请日期 |
2014.09.11 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
SCHICKLI, JEANNE;TANG, RODERICK;LAWLOR, HEATHER |
分类号 |
A61K39/155;C07K7/06;C07K14/78;C07K16/10;C12N7/04;C12N15/45 |
主分类号 |
A61K39/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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