发明名称 |
NANOSCALE CARRIERS FOR THE DELIVERY OR CO-DELIVERY OF CHEMOTHERAPEUTICS, NUCLEIC ACIDS AND PHOTOSENSITIZERS |
摘要 |
Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described. |
申请公布号 |
WO2015069926(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
WO2014US64388 |
申请日期 |
2014.11.06 |
申请人 |
THE UNIVERSITY OF CHICAGO;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
LIN, WENBIN;HE, CHUNBAI;LIU, DEMIN |
分类号 |
A61K9/14;C12N15/11 |
主分类号 |
A61K9/14 |
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