Mulit-Phasic Solid Implants for Tissue Repair

摘要

This invention provides aragonite- and calcite-based solid substrates for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which solid substrates comprise or are made to ultimately comprise three phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, and methods of use thereof.

主权项

1. A solid substrate for tissue repair, said solid substrate consisting essentially of three phases wherein:
a first phase of said three phases comprised substantially of a first biocompatible polymer, which first phase is characterized by being comprised of an elastic material which is substantially less rigid in structure than that of said second and third phases of said three phases; a second phase of said three phases comprises a marine organism skeletal derivative-based solid substrate further comprising a second biocompatible polymer, wherein said second phase further comprises a series of hollows along a longitudinal axis in said second phase, and wherein said second biocompatible polymer is substantially located within said series of hollows; and a third phase of said three phases comprises a marine organism skeletal derivative-based solid substrate, optionally comprising a series of hollows along a longitudinal axis in said third phase.