SYSTEM AND METHOD FOR INTRAOPERATIVE DETECTION OF CANCER MARGINS USING CONFORMAL FILTERS IN A DUAL POLARIZATION CONFIGURATION

摘要

Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.

主权项

1. A system comprising:
an intraoperative optical diagnostic device configured to detect features of a biological sample comprising: an optical separator positioned to receive interacted photons from the biological sample and configured to separate the interacted photons into a first optical path and a second optical path; a first conformal filter positioned to receive interacted photons from the first optical path, the first conformal filter having one or more filter stages configured to filter the interacted photons in the first optical path and generate a first filtered component; a second conformal filter positioned to receive interacted photons from the second optical path, the second conformal filter having one or more filter stages configured to filter the second optical component and generate a second filtered component; a controller operably connected to the first conformal filter and the second conformal filter, the controller being configured to apply voltage to each of the one or more filter stages of the first conformal filter and each of the one or more filter stages of the second conformal filter; and one or more detectors positioned to receive the first filtered component, the second filtered component or combinations thereof, each of the one or more detectors being configured to detect the first filtered component, the second filtered component, and combinations there and generate image data from the first filtered component, the second filtered component, or combinations thereof; and a processor operably connected to each of the one or more detectors and the controller, the processor being configured to analyze the image data and generate images related thereto, the processor further being capable of causing the controller to individually apply voltage to each stage of each of the first conformal filter and the second conformal thereby individually tuning the each of the first conformal filter and second conformal filter.