BENZOFURAN COMPOUNDS, COMPOSITIONS, KITS AND/OR METHODS THEREOF

摘要

Benzofuran compound, composition thereof, kit thereof, and/or method thereof. A benzofuran-2-carboxamide moiety may be N-arylated and/or N-alkylated, and the resulting benzofuran compound may be a sigma receptor ligand that binds to, e.g., a σ1 receptor and/or a σ2 receptor with relatively high affinity and/or selectivity. For example, the benzofuran compound may be 5,6-dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide, 3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide, or 6-methoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide. The composition may include the benzofuran compound and a pharmaceutically acceptable carrier.

主权项

1. A composition comprising:
a pharmaceutically acceptable carrier; and a compound of Formula I: wherein R1 and R2 are independently selected from C1-20-alkyl, C1-20-alkoxy, and hydrogen, R3 is independently selected from 3-(piperidin-1yl)C1-20-alkyl, and R4 is independently selected from C1-20-alkyl, a functional group, and hydrogen.