MULTICOMPONENT CRYSTALS COMPRISING DASATINIB AND SELECTED CO-CRYSTAL FORMERS

摘要

Provided are a multicomponent crystalline system (co-crystal), use thereof, as well as a process for obtaining the same. The said multicomponent crystalline system (co-crystal) comprises Dasatinib and a second compound selected from methyM-hydrobenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, or (1R,2S,5R)-(−)-menthol.;

主权项

1. A multicomponent crystalline system comprising:
a compound of formula 1and
a second compound selected from the group consisting of methyl-4-hydroxybenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, and (1R,2S,5R)-(−)-menthol.