发明名称 Method of Making an Aluminum Salt Composition
摘要 A method of making aluminum salt compositions using a combination of a basic organic buffer with a source of alkaline earth metal ions. This selection of basic organic buffer provides for a lower alkaline earth metal salt content in the composition made by the method.
申请公布号 US2015132242(A1) 申请公布日期 2015.05.14
申请号 US201214395307 申请日期 2012.04.17
申请人 Yuan Shaotang;Pan Long;Vaughn John;Pappas Iraklis;Masters James 发明人 Yuan Shaotang;Pan Long;Vaughn John;Pappas Iraklis;Masters James
分类号 A61K8/26;A61Q15/00;A61K8/28 主分类号 A61K8/26
代理机构 代理人
主权项 1. A method of making an aluminum salt composition comprising: I) heating an aqueous solution of an aluminum chloride compound having an aluminum to chloride molar ratio of 0.3:1 to 3:1 to a temperature of at least 50° C. to reflux temperature for a period of time of at least 1 hour; II) providing an aqueous solution containing a source of an alkaline earth metal to obtain a pH adjusted aluminum salt solution having a pH of 2 to 5; and wherein at least one basic organic buffer is included with at least one of I) the aqueous solution of the aluminum and chloride containing salt, and II) the aqueous solution containing the alkaline earth metal, wherein the pH adjusted aluminum salt solution has an aluminum salt with an OH:Al molar ratio of 2:1 to 2.6:1, wherein a basic organic buffer to alkaline earth metal ion molar ratio is 0.22:1 to 18:1.
地址 East Brunswick NJ US