SYSTEMS, METHODS, AND VISUALIZATION TOOLS FOR STIMULATION AND SENSING OF NEURAL SYSTEMS WITH SYSTEM-LEVEL INTERACTION MODELS

摘要

A computer implemented system and method generates a patient-specific model of patient response to stimulation on a neural element basis, receives user-input of target neuromodulation sites, and, based on the patient-specific model, determines which stimulation paradigm and settings, including stimulation sites, would result in the target neuromodulation, where the stimulation sites are not necessarily the same as the resulting neuromodulation sites. The system outputs a visual representation of the stimulation sites that would result in the target neuromodulation. The system monitors a system state and/or patient state and dynamically changes which stimulation program to implement based on the state.

主权项

1. A computer-implemented method comprising:
receiving, by a computer processor, user input selecting a neuromodulation effect region of a patient; and responsive to the input, determining, by the processor, electrode neuromodulation settings estimated by the processor to, when applied to an implanted electrode leadwire, produce a volume of tissue activation that at least partially encompasses at least one target anatomical stimulation candidate region which is mapped by the processor to, and is at a distance from, the selected neuromodulation effect region; wherein at least one of:
the leadwire is implanted in the patient's brain;the at least one target anatomical stimulation candidate region includes a plurality of distinct regions;the user input specifies the neuromodulation effect region as a region at which neural activity is to be reduced; andthe mapping at least one of:
is based on a susceptibility weighted imaging (SWI) image;is based on a probabilistic tractography model; andincludes a patient-specific mapping that is specific to the patient and that is based on response information indicating prior responses by the patient to previous neuromodulations.