METHOD OF PREPARING OXYMORPHONE

摘要

The invention relates to an improved method of preparing oxymorphone or a salt thereof from oripavine. In particular, the invention relates to a method of preparing oxymorphone with a content of alpha-beta-unsaturated ketones (ABUK) <10 ppm, wherein the content of 8,14-dihydroxydihydromorphinone in the prepared oxymorphone is >10 ppm.

主权项

1. A method of preparing oxymorphone or a salt thereof, comprising:
i) oxidizing oripavine to obtain 14-hydroxymorphinone; ii) reducing the 14-hydroxymorphinone to obtain oxymorphone; and optionally iii) producing an oxymorphone salt by treating the oxymorphone from ii) with an acid to produce an oxymorphone salt; characterized in that the reducing step ii) proceeds without the use of strong acid.