发明名称 COMPOUNDS AND THEIR USE AS BACE INHIBITORS
摘要 The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
申请公布号 US2015133471(A1) 申请公布日期 2015.05.14
申请号 US201414486959 申请日期 2014.09.15
申请人 ASTRAZENECA AB 发明人 Csjernyik Gabor;Karlstrom Sofia;Kers Annika;Kolmodin Karin;Nylof Martin;Ohberg Liselotte;Rakos Laszlo;Sandberg Lars;Sehgelmeble Fernando;Soderman Peter;Swahn Britt-Marie;Von Berg Stefan
分类号 A61K31/506;A61K31/437;A61K31/497;A61K31/4184;A61K31/4188;A61K31/4439 主分类号 A61K31/506
代理机构 代理人
主权项
地址 SODERTALJE SE