| 发明名称 |
COMPOSITIONS AND METHODS FOR DIMINISHING AN IMMUNE RESPONSE |
| 摘要 |
The invention is based upon the discovery that T regulatory type 1 (Tr1) cells express particular cell surface markers that allow for their selection, enrichment, isolation, purification and administration. The ability to use the particular markers described herein to select, enrich, isolate, purity and administer Tr1 cells allows for improved methods of Tr1 therapies for treating a wide variety of diseases and disorders. |
| 申请公布号 |
US2015132272(A1) |
申请公布日期 |
2015.05.14 |
| 申请号 |
US201314407627 |
申请日期 |
2013.06.18 |
| 申请人 |
Yale University ;Ospedale San Raffaele Srl ;Fondazione Telethon |
发明人 |
Flavell Richard A.;Gagliani Nicola;Gregori Silvia;Huber Samuel;Magnani Chiara Francesca;Roncarolo Maria Grazia |
| 分类号 |
C12N5/0783;A61K35/17 |
主分类号 |
C12N5/0783 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A composition comprising an enriched population of T regulatory type 1 (Tr1) cells, wherein the Tr1 cells in the enriched population of Tr1 cells express the cell surface markers CD4, and CD49b, and LAG-3. |
| 地址 |
New Haven CT US |
