METHODS OF MAKING L-ORNITHINE PHENYL ACETATE

摘要

Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, intermixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.

主权项

1. A process for making L-ornithine phenyl acetate salt comprising:
preparing a solution of sodium phenyl acetate by mixing a phenyl acetic acid and sodium hydroxide in a solvent; intermixing L-ornithine benzoate with the solution of sodium phenyl acetate; and isolating a composition comprising L-ornithine phenyl acetate.