HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES

摘要

We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific. These are promising therapeutic agents.

主权项

1. A bispecific polypeptide, comprising:
a first single chain human variable region which binds to EGFRvIII, and comprises segments encoded by SEQ ID NO: 2 and 3; in series with a second single chain human variable region which binds to T cell activation ligand CD3 and comprises segments encoded by SEQ ID NO: 5 and 6;