Polypeptide Having Antibacterial Activity and Angiogenesis-Inducing Activity and Wound-Healing Drug Containing Said Polypeptide

摘要

A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a burns, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.

主权项

1. A method for the prevention, amelioration or treatment of a disease or disorder in a mammal, wherein said disease or disorder is selected from the group consisting of: burns, wounds, erosions, skin ulcers or intractable wounds, said method comprising administering to said mammal an effective amount of a polypeptide comprising the amino acid sequence of SEQ ID NO:8 or SEQ ID NO:10.