| 摘要 |
The invention comprises dibenzo[b.f.]-azepine and -dihydroazepine derivatives of the general formula <FORM:0901691/IV (b)/1> (wherein X represents -CH = CH- or -CH2-CH2-, p each Y represents a hydrogen or halogen atom, R1 and R2 represent C1-4 alkyl radicals, R3 represents a hydrogen atom or a C1-4 alkyl radical, and alkylene represents a C2-4 alkylene radical, or <FORM:0901691/IV (b)/2> represents a piperazine ring substituted at the second nitrogen atom by a C1-4 alkyl radical) and their mono- and di-acid-addition salts and quaternary ammonium compounds, and the preparation thereof by reacting a 5-(21,31-epoxypropyl)-azepine or -dihydroazepine of the general formula <FORM:0901691/IV (b)/3> with a diamine of the formula <FORM:0901691/IV (b)/4> and, if desired, converting the product into a salt by treatment with an inorganic or organic acid or into a quaternary ammonium compound by reaction with a reactive ester of an aliphatic or araliphatic alcohol. The products have spasmolytic, anti-allergic and hypnotic activity. 5-(21,31-Epoxypropyl)-azepines and -dihydroazepines of the general formula (II) above are prepared by reacting the alkali metal compounds of the corresponding 5-unsubstituted compounds with epichlorhydrin. Reference has been directed by the Comptroller to Specification 820,476. |
