发明名称 |
CARBOXYMETHYL PIPERIDINE DERIVATIVE |
摘要 |
The present invention provides a novel compound useful in the prevention or treatment of nausea and vomiting associated with the administration of antineoplastics, the compound having an NK1 receptor-antagonizing effect, and an inhibitory effect on CYP3A4 that is attenuated to a greater extent than in aprepitant. Specifically, the present invention relates to a carboxymethyl piperidine derivative represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, ring A is a benzene ring or the like, ring B is a pyridine ring or the like, R1 is a C1-6 alkyl or C1-6 alkoxy, R2 and R3 are hydrogen atoms or methyl, and n represents an integer of from 0 to 5. |
申请公布号 |
CA2930008(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
CA20142930008 |
申请日期 |
2014.11.06 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
SHIMIZU, KAZUO;MIYAGI, TAKASHI;OHNO, KOHSUKE;UENO, YASUNORI;ONDA, YUSUKE;SUZUKI, HIKARU |
分类号 |
C07D401/04;A61K31/4545;A61P1/08;A61P35/00;A61P43/00;C12N15/09 |
主分类号 |
C07D401/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|