| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for 2-sulfation of glycosides.SOLUTION: The present invention includes (a) treating a glycoside having hydroxyl groups at positions 2 and 4 in a cis relationship with a tin reagent to provide a glycoside 2,4-stannylene acetal, and (b) a method for treating the 2,4-stannylene acetal with a sulfating agent to obtain a 2-sulfated glycoside. In the above method, a tin reagent is a dibutyltin (IV) oxide, a sulfating agent is a sulfur trioxide complex selected from the group consisting of a sulfur trioxide complex with trimethylamine, sulfur trioxide complex with pyridine, and sulfur trioxide N,N dimethylformamide complex. |
