CANCER CELL DETECTION USING DIELECTROPHORETIC DYNAMIC LIGHT SCATTERING (DDLS) SPECTROSCOPY

摘要

Non-invasive apparatus and method for determining and monitoring glucose concentrations in human subjects. Glucose level is estimated through the effect of glucose on biological cells with glucose dependencies, e.g., red blood cells. The invention is based on the interaction of such cells with oscillating electric field gradients. The response of biological cells depends on factors including shape, size, and electrical charge distribution. The field gradient causes the cells to undergo characteristic motion which is detected by light beam scattering. The autocorrelation of the scattered light is computed, and the Fourier transform (FT) is performed to produce a characteristic velocity spectrum in which the peaks are characteristic of the cell “bio-electrical” states. The glucose level is estimated through measurements of changes of FT with changes in glucose levels after calibration with standard glucose methods.

主权项

1. A portable non-invasive cancer detection device comprising:
a probe configured to present an oscillating, non-uniform electric field onto a predetermined part of a human body; said probe also configured to present a collimated light beam onto said predetermined part and to direct scattered light into a detector; a processor in communication with said probe, said processor executing a program that produces a time-autocorrelation related to said scattered light; said program comparing said autocorrelation, or a function of said autocorrelation, against a calibration to detect presence of cancer cells in said predetermined part.