METHODS AND COMPOSITIONS FOR POSITRON EMISSION TOMOGRAPHY MYOCARDIAL PERFUSION IMAGING

摘要

This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.

主权项

1. A multi-unit molecule useful as an imaging tracer, comprising:
one or more cationic unit(s); one or more sar multifunctional chelator unit(s); and one or more hydrophobic unit(s), wherein said TPP unit(s), sar multifunctional chelator unit(s) and hydrophobic unit(s) may be linked direct to each other or via a linker arranged in any sequential order in a linear linkage.