IDENTIFICATION OF ATYPICAL ANTIBODIES IN HUMAN BLOOD AND BLOOD PRODUCTS

摘要

A method identifies atypical antibodies in blood or blood product manufacturing processes that may produce false positives in quality control testing on intermediate or final products.

主权项

1. A method for identifying atypical reactive antibodies in a blood products manufacturing process, the method comprising:
(a) obtaining a sample of blood or plasma; (b) testing the sample and a control using any one or more of cellular agglutination, fluorescence microscopy, immunoprecipitation, immunodiffusion, immunofluorescence, ELISA, flow cytometry, FACS, or Western blotting; (c) comparing the sample and control testing results; (d) determining whether the sample contains reactive atypical antibodies; and; (e) interdicting a blood or plasma unit that was the source of the sample if the sample contains reactive atypical antibodies.