Microfluidic Devices Formed From Hydrophobic Paper

摘要

Microfluidic devices fabricated from paper that has been covalently modified to increase its hydrophobicity, as well as methods of making and using thereof are provided herein. The devices are typically small, portable, flexible, and both easy and inexpensive to fabricate. Microfluidic devices contain a network of microfluidic components, including microfluidic channels, microfluidic chambers, microwells, or combinations thereof, designed to carry, store, mix, react, and/or analyze liquid samples. The microfluidic channels may be open channels, closed channels, or combinations thereof. The microfluidic devices may be used to detect and/or quantify an analyte, such as a small molecules, proteins, lipids polysaccharides, nucleic acids, prokaryotic cells, eukaryotic cells, particles, viruses, metal ions, and combinations thereof.

主权项

1. An open channel microfluidic device comprising:
a device having a bottom and two side walls that define an open channel for receiving fluid, wherein the bottom and side walls of the open channel are formed from a hydrophobic cellulosic substrate, wherein the cellulosic substrate has been covalently modified to increase its hydrophobicity.