发明名称 |
PROCESS FOR SORAFENIB TOSYLATE POLYMORPH III |
摘要 |
The present invention provides a novel process for the preparation of sorafenib tosylate polymorph III. |
申请公布号 |
US2015133670(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
US201314401191 |
申请日期 |
2013.05.21 |
申请人 |
HETERO RESEARCH FOUNDATION |
发明人 |
Parthasaradhi Reddy Bandi;Rathnakar Reddy Kura;Muralidhara Reddy Dasari;Srinivasa Rao Thungathurthy;Vamsi Krishna Bandi |
分类号 |
C07D213/81 |
主分类号 |
C07D213/81 |
代理机构 |
|
代理人 |
|
主权项 |
1. A process for the preparation of sorafenib tosylate polymorph III, which comprises:
a. providing a solution comprising sorafenib, p-toluenesulfonic acid and a solvent selected from a group consisting of a mixture of dimethyl acetamide and an alcoholic solvent, a mixture of dimethylformamide and an alcoholic solvent and a mixture thereof; b. adding an alcoholic solvent to the solution obtained in step (a); c. isolating the solid; d. slurring the solid obtained in step (c) with an alcoholic solvent; and e. isolating sorafenib tosylate polymorph III. |
地址 |
Balanagar, Hyderabad, Andhra Pradesh IN |