发明名称 |
Compositions and Methods for Treating Macular Degeneration |
摘要 |
Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation of a lipofuscin pigment in a retina are provided. These methods include the step of administering to a patient in need thereof a substituted C20-retinoid in an amount sufficient to reduce accumulation of a lipofuscin pigment in the retina. Further provided are methods of retarding formation of A2E and/or ATR-dimer by replacing an all-trans-retinal (ATR) substrate with a C20-D3-retinal substrate under conditions sufficient to impede the formation of A2E. Compositions for retarding formation of a lipofuscin pigment in the retina containing a substituted C20-retinoid and a pharmaceutically acceptable carrier are also provided. |
申请公布号 |
US2015133549(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
US201414510975 |
申请日期 |
2014.10.09 |
申请人 |
The Trustees of Columbia University in the City of New York |
发明人 |
Washington Ilyas |
分类号 |
A61K31/215;A61K31/167;A61K45/06 |
主分类号 |
A61K31/215 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
New York NY US |