MULTI-ARM POLYMERIC ALKANOATE CONJUGATES

摘要

Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

主权项

1. A method of treating a mammalian subject for a condition responsive to treatment with docetaxel, where the method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a multi-armed polymer conjugate having the structure, where n ranges from about 40 to about 500 or a pharmaceutically acceptable salt thereof; and
a pharmaceutically acceptable excipient.