COMPOSITIONS AND METHODS FOR THE TREATMENT OF COUGH

摘要

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing cough may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of acute respiratory tract infections, asthma, gout, fibromyalgia, facilitating conception, promotes secondary mucosal secretions in the respiratory system, muscle relaxant, allergy, asthma, chronic obstructive pulmonary disorders, spasms, respiratory and neurological diseases.

主权项

1. A compound of formula I:or a pharmaceutically acceptable salt, hydrate, polymorph, solvate, prodrug, enantiomer, or stereoisomer thereof;Wherein,
R1 represents H, D, CH3CO, a is independently 2, 3 or 7;each b is independently 3, 5 or 6;e is independently 1, 2 or 6;c and d are each independently H, D, —OH, C1-C6-alkyl, —NH2 or —COCH3; R represents Hydrogen (H), Acetyl (CH3CO—), R3 represents a is independently 2, 3 or 7;each b is independently 3, 5 or 6,e is independently 1, 2 or 6;c and d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3.