FOLIC ACID – RAMIPRIL COMBINATION: CELL PROTECTIVE, NEUROPROTECTIVE AND RETINOPROTECTIVE OPHTALMOLIGIC COMPOSITIONS

摘要

The invention relates to a cellprotective, neuroprotective and retinoprotective composition. In an embodiment of the invention, said composition comprises (i) Ramipril or Ramiprilate and (ii) folic acid. The composition of the invention can be used, in particular, for the prevention of loss of vision, or even for improving visual acuity and visual field in normal subjects, as well as for treating ophthalmologic pathologies, in particular: glaucoma, diabetic retinopathy, age related macular degeneration, hereditary dystrophy of the retina, uveitis, ammetropia (myopia, presbyopia). This combination of active principles could also be used in general conditions for treating general pathologies (cancer . . . ).

主权项

1. A method of preventing and/or treating macular degeneration or age related macular degeneration, with or without choroidal new vessels in an animal in need thereof, said method comprising administering to said animal two active principles, the first active principle being an angiotensin-converting enzyme inhibitor (ACEI) selected from the group consisting of Ramipril, Ramiprilat, their pharmaceutically acceptable salts or a derivative thereof, and mixtures thereof, and the second active principle being indomethacin, wherein said active principles are administered separately or not.