AGENTS AND DEVICES FOR AFFECTING NERVE FUNCTION

摘要

Agents and devices for affecting nerve function are described. In some variations, a combination of agents, e.g., a cardiac glycoside, an ACE inhibitor, and an NSAID are delivered to affect nerve function. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One variation of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.

主权项

1. A method for treating hypertension in a patient, the method comprising:
delivering a cardiac glycoside locally to a portion of a renal nerve in an amount that affects function of the renal nerve and lowers blood pressure of the patient.