INHIBITION OF NT-3:TRKC BOUND AND APPLICATION TO TREATMENT OF CANCER SUCH AS NEUROBLASTOMA

摘要

PROBLEM TO BE SOLVED: To provide an in vitro method for selecting compounds for prevention or treatment of a cancer, an in vitro method for predicting presence of metastatic cancer or progressive cancer, particularly a bad prognosis neuroblastoma, in patients having primary tremor, and kits for selecting compounds for prevention or treatment of cancer.SOLUTION: Disclosed is an in vitro method for screening of anti-cancer compounds based on a capacity to interact with neurotrophin 3, or an extracellular domain or TrkC receptor and/or to inhibit dimerization of an intracellular domain of the TrkC receptor expressed in a tumor cell, particularly neuroblastoma. The disclosure also relates to a method for predicting presence of metastatic cancer or a bad prognosis cancer, or for determining efficacy of an anti-cancer treatment on the basis of a measurement of an expression level of the neurotrophin 3. The disclosure further relates to kits and compounds as a medicament for the treatment of the neuroblastoma or cancer overexpressing the neurotrophin 3 by the tumor cell.