SYSTEMS AND METHODS FOR CORRECTING OPTICAL REFLECTANCE MEASUREMENTS

摘要

We disclose measurement systems and methods for measuring analytes in target regions of samples that also include features overlying the target regions. The systems include: (a) a light source; (b) a detection system; (c) a set of at least first, second, and third light ports which transmit light from the light source to a sample and receive and direct light reflected from the sample to the detection system, generating a first set of data including information corresponding to both an internal target within the sample and features overlying the internal target, and a second set of data including information corresponding to features overlying the internal target; and (d) a processor configured to remove information characteristic of the overlying features from the first set of data using the first and second sets of data to produce corrected information representing the internal target.

主权项

1. A measurement system, comprising:
(a) a plurality of light emitting diodes (LEDs) adapted to transmit light to an in vivo sample comprising skin, fat, and muscle; (b) a detection system adapted to receive light reflected from the sample, wherein the detection system generates a first data set corresponding to a first detection distance and comprising spectral absorbance or reflectance values corresponding to both muscle within the sample, and skin and fat overlying the muscle, and a second data set corresponding to a second detection distance and comprising spectral absorbance or reflectance values corresponding to skin and fat overlying the muscle; and (c) a processor adapted to use spectral absorbance or reflectance values characteristic of the skin and fat from the first data set and the second data set to produce corrected spectral absorbance or reflectance values representing the muscle; wherein the processor is adapted to normalize the first and second data sets prior to producing the corrected spectral absorbance or reflectance values.