COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

摘要

Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

主权项

1. A compound represented by formula (I) wherein
Q is a group of formula Q1, Q2, or Q3 Z is H or OH;Y is Y′ or Y1 which are divalent groups of formula: wherein
A1 and A2 are independently absent or (C1-C6)alkylene;B is absent or is selected from the group consisting of arylene and heteroarylene, optionally substituted by one or more groups selected from halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, and (C1-C6)alkoxy;C is absent or is —OC(O)— or is one of the following groups C1-C3 wherein R4 is H or linear or branched (C1-C4)alkyl;D is absent or is selected from the group consisting of arylene and heteroarylene, optionally substituted by one or more (C1-C6)alkyl groups;n and n′ are independently 0 or an integer from 1 to 3;E is absent or is —O— or —OC(O)—;G is arylene;R1 and R2 are independently H or aryl;R3 is a group of formula J1 or J2 wherein R5 is a group of formula K wherein p′ is 0 or 1, P is absent or is CO, q is absent or is 1 and W is heteroaryl,or a pharmaceutically acceptable salt thereof.