| 摘要 |
Monoclonal antibodies exhibiting an VH4 signature associated with multiple sclerosis (MS) and clinically isolated syndrome have been produced and sequenced. These antibodies antibodies recognize neuronal nuclei and/or astrocytes in both mouse and human gray matter (GM) brain tissue and thus are useful in binding assays for such. They are also useful in the production of MS animal models, and as targets for MS therapies. |
