发明名称 |
CELL PENETRATING PEPTIDES TO TARGET EIF4E |
摘要 |
The present invention provides compounds to disrupt the eIF4E-eIF4G interaction and pharmaceutically acceptable salts of such compounds. Generally, the compounds are cell-penetrating peptides which bind mammalian initiation factor eIF4E (CPP-eIF4E), wherein the peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOS: 7, 9-11, 12-26, 27-44 and 45-51. More preferably, the amino acid sequence comprises at least 9 to about 40 amino acids and the mammalian initiation factor eIF4E is human initiation factor eIF4E. |
申请公布号 |
EP2870174(A1) |
申请公布日期 |
2015.05.13 |
申请号 |
EP20130734091 |
申请日期 |
2013.07.05 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
DANHO, WALEED;FOTOUHI, NADER;HAN, YI;KHAN, WAJIHA;MILLETTI, FRANCESCA;NUI, HUIFENG |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|