| 发明名称 |
COVALENTLY LINKED ANTIGEN-ANTIBODY CONJUGATES |
| 摘要 |
Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof. |
| 申请公布号 |
EP2869848(A1) |
申请公布日期 |
2015.05.13 |
| 申请号 |
EP20130737565 |
申请日期 |
2013.07.04 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
BENZ, JOERG;BRINKMANN, ULRICH;DENGL, STEFAN;DZIADEK, SEBASTIAN;GEORGES, GUY;GROTE, MICHAEL;HAAS, ALEXANDER;HOFFMANN, EIKE |
| 分类号 |
A61K47/48;A61K39/00;A61K39/385;B82Y5/00;C07K16/00;C07K16/16;C07K16/28;C07K16/40;C07K16/44;C07K16/46;G01N33/68 |
主分类号 |
A61K47/48 |
| 代理机构 |
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