SYSTEM AND METHOD FOR USING ULTRASOUND-STIMULATED MICROBUBBLE EXPOSURES TO INDUCE CERAMIDE ACCUMULATION IN ENDOTHELIAL AND TUMOR CELLS
摘要
A system and method for using ultrasound and a microbubble agent to induce ceramide accumulation in a target region including a population of cells associated with a tumor. An ultrasound system is directed to expose a target region in a patient, to which a microbubble agent has been provided, to an ultrasound exposure sufficient to alter gene expressions in cells in the target region so as to induce an accumulation of ceramide in the cells.
申请公布号
EP2869815(A1)
申请公布日期
2015.05.13
申请号
EP20130816397
申请日期
2013.07.08
申请人
SUNNYBROOK HEALTH SCIENCES CENTRE
发明人
CZARNOTA, GREGORY J.;AL-MAHROUKI, AZZA;KARSHAFIAN, RAFFI;TRAN, WILLIAM TYLER;BURNS, PETER NICHOLAS;KIM, CHRISTINA;GILES, ANOJA;WONG, EMILY