| 发明名称 |
ALANINYL MAYTANSINOL ANTIBODY CONJUGATES |
| 摘要 |
<p>Linker-drug intermediates of Formula I are conjugated to antibodies to form antibody-drug conjugates where the drug moiety is an N-methylalaninyl-maytansinoid. L is E is n is 2, 3, 4, 5, or 6; m is 2, 3 or 4; and q is 0 or 1.</p> |
| 申请公布号 |
EP2640727(B1) |
申请公布日期 |
2015.05.13 |
| 申请号 |
EP20110793586 |
申请日期 |
2011.11.16 |
| 申请人 |
GENENTECH, INC. |
发明人 |
FLYGARE, JOHN;JUNUTULA, JAGATH REDDY;PILLOW, THOMAS |
| 分类号 |
C07D491/12;A61K31/535;A61K39/00 |
主分类号 |
C07D491/12 |
| 代理机构 |
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代理人 |
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