Silica nanoparticle agent conjugates

摘要

The invention provide a silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises, for example, an ester, urea, thiourea, or thio ether group, and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm. The invention also provides novel methods of making and using the silica nanoparticles described herein.

主权项

1. A silica nanoparticle comprising a non-porous matrix of silicon-oxygen bonds, wherein the matrix comprises organic agents conjugated to silicon or oxygen atoms in the matrix, the organic agents are located inside the surface of the nanoparticle or both inside the surface of the nanoparticle and on the surface of the nanoparticle, the organic agents are conjugated to the matrix through linker L groups, wherein the linker L comprises an ester, acetal, urea, thiourea, or thio ether group, wherein the silica nanoparticle matrix comprises responsively degradable Si-ester-Si groups, degradable Si-acetal-Si groups, or both, dispersed throughout the matrix; and wherein the diameter of the nanoparticle is about 15 nm to about 200 nm.